In Advances in Drug Research, 3 Action of Aldose Reductase Inhibitors. Most aldose reductase inhibitors (e.g. sorbinil, alrestatin, tolrestat and ponalrestat) inhibit the enzyme in a non-competitive or uncompetitive way – they compete neither with the substrate nor with the cofactor (NADPH). Therefore, an inhibitory binding site in the enzyme is postulated (Sarges, ). In enzymology, aldose reductase (or aldehyde reductase) (EC ) is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose rouwverzen.net: BRENDA entry. Inhibitors of Aldose Reductase Enzyme Depending on the previous observations, development of many aldose reductase inhibitors as possible therapeutic agents (with diverse chemical structures) for diabetic complications (to prevent retinal damage, cataracts, and nerve damage) became critical. The clinical efficacy of Sorbinil, ponalrestat, and.
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